Publications 1990-1999


Publication Information (Click the authors' names to retrieve the abstract)

Flow cytometry

Natarajan A, Srienc F.

Dynamics of glucose uptake by single Escherichia coli cells.
Metab Eng. 1999 Oct;1(4):320-33.


Abu-Absi,N.R. & Srienc,F. (1999)

Cell cycle events and cell cycle dependent processes in eukaryotic cells. Encyclopedia of Cell Technology (ed. by S.W.D.Flickinger and), John Whiley.

Polyhydroxyalkanoate production

Jackson,J.K. & Srienc,F. (1999)

Effects of recombinant modulation of the phbCAB operon copy number on PHB synthesis rates in Ralstonia eutropha. J.Biotechnol. 68, 49-60.

Population modeling

Mantzaris,N.V.,Daoutidis,P., Srienc,F., & Fredrickson,A.G. (1999)

Growth processes in a cascade of bioreactors: Mathematical models. AIChE J. 45, 164-176.

Population modeling

Mantzaris,N.V., Daoutidis,P., Srienc,F., & Fredrickson,A.G. (1999)

Growth processes in a cascade of bioreactors: Comparison of modeling approaches. AIChE J. 45, 177-189

Population modeling

Mantzaris,N.V., Liou,J.J., Daoutidis,P., & Srienc,F. (1999)

Numerical solution of a mass structured cell population balance model in an environment of changing substrate concentration. J.Biotechnol. 71, 157-174.

Flow cytometry

Natarajan,A., Dunny,G., & Srienc,F. (1999)

Flow cytometric analysis of growth of two Streptococcus gordonii derivatives. J.Microbiol.Meth. 34, 223-233.

Flow cytometry

Natarajan,A. & Srienc,F.(1999)  Dynamics of glucose uptake by single Escherichia coli cells. Metabol.Eng. 1, 320- 333.


Ramkrishna,D. & Srienc,F. (1999)

In honor of Arnold G. Fredrickson. J.Biotechnol. 71 , 3-5.


Ramkrishna,D. & Srienc,F. (1999)

Special Issue - Modelling in biochemical engineering. J.Biotechnol. 71, 1-1.

Population modeling, Flow cytometry

Srienc,F. (1999)

Cytometric data as the basis for rigorous models of cell population dynamics. J.Biotechnol. 71, 233-238.

Polyhydroxyalkanoate production

Kelley AS, Srienc F.

Production of two phase polyhydroxyalkanoic acid granules in Ralstonia eutropha.
Int J Biol Macromol. 1999 Jun-Jul;25(1-3):61-7.

Flow cytometry

Zhao R, Natarajan A, Srienc F.

A flow injection flow cytometry system for on-line monitoring of bioreactors.
Biotechnol Bioeng. 1999 Mar 5;62(5):609-17.

Polyhydroxyalkanoate production

Kelley,A.S., Jackson,D.E., Macosko,C., & Srienc,F. (1998)

Engineering the composition of co-polyesters synthesized by Alcaligenes eutrophus. Polym.Degrad.Stab. 59, 187-190.

Flow cytometry

Frykman S, Srienc F.

Quantitating secretion rates of individual cells: design of secretion assays.
Biotechnol Bioeng. 1998 Jul 20;59(2):214-26.

Polyhydroxyalkanoate production, Metabolic modeling

Leaf TA, Srienc F.

Metabolic modeling of polyhydroxybutyrate biosynthesis.
Biotechnol Bioeng. 1998 Mar 5;57(5):557-70.

Flow cytometry

Natarajan A, Subramanian S, Srienc F.

Comparison of mutant forms of the green fluorescent protein as expression markers in Chinese hamster ovary (CHO) and Saccharomyces cerevisiae cells.
J Biotechnol. 1998 Jun 11;62(1):29-45.


Liou JJ, Fredrickson AG, Srienc F.

Selective synchronization of Tetrahymena pyriformis cell populations and cell growth kinetics during the cell cycle.
Biotechnol Prog. 1998 May-Jun;14(3):450-6.

Polyhydroxyalkanoate production

Hahn JJ, Eschenlauer AC, Narrol MH, Somers DA, Srienc F.

Growth kinetics, nutrient uptake, and expression of the Alcaligenes eutrophus poly(beta-hydroxybutyrate) synthesis pathway in transgenic maize cell suspension cultures.
Biotechnol Prog. 1997 Jul-Aug;13(4):347-54.

Flow cytometry

Hatzis,C., Fredrickson,A.G., & Srienc,F. (1997)

Cell-cycle analysis in phagotrophic microorganisms from flow cytometric histograms. J.Theor.Biol. 186, 131-144.

Population modeling

Liou,J.J., Srienc,F., & Fredrickson,A.G. (1997)

Solutions of population balance models based on a successive generations approach. Chem.Eng.Sci. 52, 1529-1540.


Scheper,T., Freitag,R., & Srienc,F. (1997)

On-line and off-line process analysis. Mammalian Cell Biotechnology in Protein Production (ed. by H.Hauser and R.Wagner), pp. 373-410. Walter de Gruyter, Berlin, New York.


Subramanian,S. & Srienc,F. (1997)

The green fluorescent protein (Gfp) as a tool for the analysis of gene expression in mammalian cells. Cell & Tissue Culture: Laboratory Procedures (ed. by A.Doyle and J.B.Griffiths), pp. 1-14.

Flow cytometry

Subramanian S, Srienc F.

Quantitative analysis of transient gene expression in mammalian cells using the green fluorescent protein.
J Biotechnol. 1996 Aug 20;49(1-3):137-51.

Polyhydroxyalkanoate production

Eschenlauer AC, Stoup SK, Srienc F, Somers DA.

Production of heteropolymeric polyhydroxyalkanoate in Escherichia coli from a single carbon source.
Int J Biol Macromol. 1996 Aug;19(2):121-30.

Polyhydroxyalkanoate production

Leaf TA, Peterson MS, Stoup SK, Somers D, Srienc F.

Saccharomyces cerevisiae expressing bacterial polyhydroxybutyrate synthase produces poly-3-hydroxybutyrate.
Microbiology. 1996 May;142 ( Pt 5):1169-80.


Schweizer L, Yerk-Davis GL, Phillips RL, Srienc F, Jones RJ.

Dynamics of maize endosperm development and DNA endoreduplication.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7070-4.

Flow cytometry

Porro D, Srienc F.

Tracking of individual cell cohorts in asynchronous Saccharomyces cerevisiae populations.
Biotechnol Prog. 1995 May-Jun;11(3):342-7.

Population modeling

Hatzis C, Srienc F, Fredrickson AG.

Multistaged corpuscular models of microbial growth: Monte Carlo simulations.
Biosystems. 1995;36(1):19-35.

Flow cytometry

Cherlet,M., Kromenaker,S.J., & Srienc,F. (1995)

Surface IgG content of murine hybridomas: direct evidence for variation of antibody secretion rates during the cell cycle. Biotechnol.Bioeng. 47, 535-540.

Polyhydroxyalkanoate production

Jackson DE, Srienc F.

Novel methods to synthesize polyhydroxyalkanoates.
Ann N Y Acad Sci. 1994 Nov 30;745:134-48.

Flow cytometry

Kromenaker SJ, Srienc F.

Stability of producer hybridoma cell lines after cell sorting: a case study.
Biotechnol Prog. 1994 May-Jun;10(3):299-307.

Flow cytometry

Kromenaker SJ, Srienc F.

Effect of lactic acid on the kinetics of growth and antibody production in a murine hybridoma: secretion patterns during the cell cycle.
J Biotechnol. 1994 Apr 30;34(1):13-34.


Sun L, Jacobson BA, Dien BS, Srienc F, Fuchs JA.

Cell cycle regulation of the Escherichia coli nrd operon: requirement for a cis-acting upstream AT-rich sequence.
J Bacteriol. 1994 Apr;176(8):2415-26.

Flow cytometry

Kromenaker SJ, Srienc F.

Cell cycle kinetics of the accumulation of heavy and light chain immunoglobulin proteins in a mouse hybridoma cell line.
Cytotechnology. 1994;14(3):205-18.

Flow cytometry

Dien BS, Peterson MS, Srienc F.

Cell-cycle analysis of Saccharomyces cerevisiae.
Methods Cell Biol. 1994;42 Pt B:457-75.

Population modeling

Hatzis,C., Srienc,F., & Fredrickson,A.G. (1994)

Feeding heterogeneity in ciliate populations: effects of culture age and nutritional state. Biotechnol.Bioeng. 43, 371-380.

Flow cytometry

Sweeney,P.J., Srienc,F., & Fredrickson,A.G. (1994)

Measurement of unequal DNA partitioning in Tetrahymena pyriformis using slit-scanning flow cytometry. Biotechnol.Progr. 10, 19-25.

Population modeling

Hatzis,C., Sweeney,P.J., Srienc,F., & Fredrickson,A.G. (1993)

Determination of cellular rate distributions in microbial cell populations: feeding rates of ciliated protozoa. Biotechnol.Bioeng. 42, 284-294.


Kromenaker,S.J. & Srienc,F. (1993)

Cell-Cycle Dynamics of Antibody Formation in Hybridomas. Animal Cell Technology: Basic & Applied Aspects (ed. by S.Kaminogawa, A.Ametani, and S.Hachimura), pp. 535-541. Kluwer Acad., Dordrecht.

Flow cytometry

Srienc F, Dien BS.

Kinetics of the cell cycle of Saccharomyces cerevisiae.
Ann N Y Acad Sci. 1992 Oct 13;665:59-71.

Flow cytometry

Fredrickson AG, Hatzis C, Srienc F.

A statistical analysis of flow cytometric determinations of phagocytosis rates.
Cytometry. 1992;13(4):423-31.

Flow cytometry

Jones,R.J., Srienc,F., & Roessler,J.R. (1992)

Flow cytometric determination of light scattering and absorbance properties of starch granules. Starch/ Starke 44, 243-247.


Kowles,R.V., McMullen,M.D., Yerk,G.L., Phillips,R.L., Kraemer,S., & Srienc,F. (1992)

Endosperm mitotic activity and endoreduplication in maize affected by defective kernel mutations. Genome 35, 68-77.


Kowles,R.V., Yerk,G.L., Srienc,F., & Phillips,R.L. (1992)

Maize endosperm tissue as an endoreduplication system. Genetic engineering: principles and methods (ed. by J.K.Setlow), pp. 65-88.


Srienc,F. (1992)

Bookreview: Bioreactor Design Fundamentals by N.G. McDuffie. AIChE J.


Eitzman PD, Srienc F.

Dynamics of activation of a galactose-inducible promoter in Saccharomyces cerevisiae.
J Biotechnol. 1991 Nov;21(1-2):63-81.

Flow cytometry

Dien BS, Srienc F.

Bromodeoxyuridine labeling and flow cytometric identification of replicating Saccharomyces cerevisiae cells: lengths of cell cycle phases and population variability at specific cell cycle positions.
Biotechnol Prog. 1991 Jul-Aug;7(4):291-8.


Block,D. & Srienc,F. (1991)

Rapid identification and isolation of zygotes and the kinetics of mating in Saccharomyces cerevisiae. Biotechnol.Tech. 5, 95-100.

Flow cytometry

Kromenaker,S.J. & Srienc,F. (1991)

Cell-cycle dependent protein accumulation by producer and non- producer murine hybridoma cell lines: a population analysis. Biotechnol.Bioeng. 38, 665-677.

Population modeling

Eitzman,P.D. & Srienc,F. (1990)

Simulation of size distributions in growing yeast populations. UMSI.Res.Rep.Series. 90, 78-78.


Kowles,R.V., Srienc,F., & Phillips,R.L. (1990)

Endoreduplication of nuclear DNA in the developing maize endosperm. Dev.Genet. 11, 125-132.

Population modeling

Hatzis C, Sweeney PJ, Srienc F, Fredrickson AG.

A discrete, stochastic model for microbial filter feeding: a model for feeding of ciliated protists on spatially uniform, nondepletable suspensions.
Math Biosci. 1990 Dec;102(2):127-81.

Flow cytometry

Block DE, Eitzman PD, Wangensteen JD, Srienc F.

Slit scanning of Saccharomyces cerevisiae cells: quantification of asymmetric cell division and cell cycle progression in asynchronous culture.
Biotechnol Prog. 1990 Nov-Dec;6(6):504-12.

Flow cytometry

Sen S, Hu WS, Srienc F.

Flow cytometric study of hybridoma cell culture: correlation between cell surface fluorescence and IgG production rate.
Enzyme Microb Technol. 1990 Aug;12(8):571-6.

Flow cytometry

Lavin DP, Fredrickson AG, Srienc F.

Flow cytometric measurement of rates of particle uptake from dilute suspensions by a ciliated protozoan.
Cytometry. 1990;11(8):875-82.


Lavin,D.P., Hatzis,C., Srienc,F., & Fredrickson,A.G. (1990)

Size limitations on the uptake of particles by populations of Tetrahymena cells. J.Protozool. 37, 157-163.

Flow cytometry

Lavin,D.P., Fredrickson,A.G., Srienc,F., Sweeney,P.J., & Hatzis,C. (1990)

Measurements of distributions of cellular process rates in growing microbial populations. Proc.Asia-Pacif.Biochem.Eng.Conf.Seoul.,Korea. 288-290.