Zasadzinski group
 

Prof. Joseph Zasadzinski

Degrees

  1. •California Institute of Technology, BS 1980

  2. •Ph.D., Chemical Engineering, University of Minnesota, 1985

  1. •    Assistant Professor, Chemical Engineering and Materials, UC Santa Barbara, 1986-1990

  2. •    Associate Professor, Chemical Engineering and Materials, UC Santa Barbara, 1990-1993

  3. •    Professor, Chemical Engineering and Materials, UC Santa Barbara, 1993-2010

  4. •    Professor Invite’ at the University of Bordeaux and the Centre de Recherche Paul Pascal, 2001

  5. •    3M Harry Heltzer Chair of Multidisciplinary Science and Technology, U. Minnesota, 2011-




Positions and Appointments

Honors

  1. •    2013 Avanti Award in Lipids of the Biophysical Society

  2. •    2009 Fellow of the American Physical Society, Division of Biological Physics,

  3. •    2004 American Chemical Society Award in Colloid and Surface Science;

  4. •    2000 Fellow of the American Association for the Advancement of Science

  5. •    1993 Burton Award of the Microscopy Society of America, 1993;

  6. •    1986 Presidential Young Investigator, 1986-1991


  1. •“Remotely Triggered Liposome Release by Near Infrared Light Absorption via Gold Nanoshells.” G. Wu, A. Mikhailovsky, H. A. Khant, C. Fu, W. Chiu and J. Zasadzinski, JACS,130, 8175-8177 (2008).

  2. • “Helical Nanofilament Phases.” L. E. Hough, H. T. Jung, D. Kruerke, M. Heberl, M. Nakata, C. Jones, D. Chen, J. Zasadzinski, G. Heppke, J. Rabe, W. Stocker, E. Korblova, D. Walba, M. Glaser and N. Clark. Science, 325 456-460 (2009).

  3. •“Interaction Forces and Adhesion of Supported Myelin Lipid Bilayers Modulated by Myelin Basic Protein,” Y. Min, K. Kristiansen, J. Boggs, C. Husted, J. A. Zasadzinski and J. N. Israelachvili. PNAS, 106, 3154-3159 (2009).

  4. •“Laser-Activated Gene Silencing via Gold Nanoshell-siRNA Conjugates,” G. Braun, G. Wu, D. Missirlis,J. Zasadzinski, M. Tirrell and N. Reich. ACS Nano 3, 2007-2015 (2009).

  5. • “Active Interfacial Microrheology of Aging Protein Films” Prajnaparamita Dhar, Yanyan Cao, Thomas Mallouk, Thomas M. Fischer, and J. A. Zasadzinski, Physical Review Letters, 104, Article Number: 016001  (2010). PMID: 20366371

  6. • “Active Microrheology of Phospholipid Monolayers: Seeing Stretching, Flowing , Yielding and Healing”  S. Y. Choi, S. Steltenkamp, A. J. Pascall, J. A. Zasadzinski and T. M. Squires. Nat. Commun., 2:312 (2011).

  7. •“Critical and Off-Critical Mixing-Demixing Transitions in Model Extracellular and Cytoplasmic Myelin Lipid Monolayers.” Y.Min, T. F. Alig, D. Lee, J. M. Boggs, J. N. Israelachvili and J. A. Zasadzinski . Biophysical Journal, 100, 1490-1498 (2011).

  8. •“Relating Domains Size Distributions to Line Tension and Molecular Dipole Density in Model Cytoplasmic Myelin Lipid Monolayers,” Y. Min, D. W. Lee, P. Dhar, A. Ramachandran, J. N. Israelachvili and J. A. Zasadzinski, PNAS, 108:9425-30. (2011).

  9. •“Design and In Situ Characterization of Lipid Containers with Enhanced Drug Retention.” B. Wong, C. Boyer, C. Steinbeck, D. Peters, R. van Zanten, B. Chmelka and J. A. Zasadzinski. Advanced Materials, 23, 2320-2325 (2011).

  10. •“Visualizing the Analogy Between Competitive Adsorption and Colloid Stability to Restore Lung Surfactant Function.” I. Shieh and J. A. Zasadzinski Biophysical Journal, 102, 777-786 (2012).

  11. •“Plasmonic Nanobubbles Enhance the Selectivity of Chemotherapy Against Drug Resistant Cancer Cells,” E. Y. Lubianova-Hleb, X. Ren, J. A. Zasadzinski, X. Wu and D. O. Lapotko, Advanced Materials, 204,3831-3837 (2012)


   

Recent Publications

Joseph A. Zasadzinski received his Ph. D. in Chemical Engineering from the University of Minnesota in 1985.  He graduated with a BS, also in Chemical Engineering, from the California Institute of Technology in 1980.  He joined the faculty at the University of California, Santa Barbara in 1986 following a post-doc at AT&T Bell Laboratories. Professor Zasadzinski received a Presidential Young Investigator Award from the NSF in 1987.  The Microscopy Society of America awarded him its Burton Award in 1993 as the outstanding microscopist under the age of 35.  In 2000, Zasadzinski became a fellow of the American Association for the Advancement of Science  and received the American Chemical Society Award in Colloid Science in 2004.  He was named a fellow of the American Physical Society for 2009.  He received the Avanti Award in Lipids from the Biophysical Society in 2013.  He was a founding member of the Materials Research Laboratory,  the California Nanoscience Institute and the Institute for Collaborative Biotechnology at UCSB.  Dr. Zasadzinski returned to the University of Minnesota in 2011 as the 3M Harry Heltzer Chair of Multidisciplinary Science and Technology.



    Dr. Zasadzinski is a pioneer in the development of modern microscopy techniques and their application to soft nanostructured materials, biomaterials and biomedicine.   He is the author of more than 220 scientific publications using optical, electron and scanning probe microscopy to determine relationships between structure and function of a wide range of nanomaterials.  Zasadzinski has innovated experimental investigations of structure, composition and function relationships at the molecular scale using optical, electron, and scanning probe microscopies.  His group is one of the few in the world to utilize all major microscopy techniques and the only such group in chemical engineering.   His current research interests include developing plasmonic gold nanoparticles that adsorb near infrared light for triggering drug and gene delivery in vivo for cancer theranostics; creating novel human lung surfactant replacements for treatment of neonatal and adult respiratory distress syndrome, and the interactions of polymers and antimicrobial peptides with monolayers and bilayers as treatments for a variety of diseases in humans and animals.